It may be different for other targeting agents and, hence, such effects have to be carefully evaluated for each single targeting concept and tumor mouse model.
A HAssLG diblock copolymer was synthesized for application in the sequential targeting concept of nanoparticles by CD44 receptor-mediated and redox-responsive drug delivery.
A specific tumor accumulation could be observed by using the folate receptor (FR) targeting concept.
The LHRH receptor targeting concept offers the possibility of replacing doxorubicin with even more potent cytotoxics, but with the advantage of increasing anticancer activity without enhancing organ toxicity.
To demonstrate broader applicability of our targeting concept, a similar study was also performed with the cervical cancer cell line HeLa (see below).
Based on feedback from experts, questions were also revised to more precisely target concepts.
A source concept that was not mappable to target concepts in SNOMED CT was recorded as "No Match".
To build the transcription factor targets concepts, KnownGene, KnownToLocusLink, and TfbsConsSites tables were obtained from UCSC Genome browser (Mar. 2006, NCBI36).
The assessment consisted of multiple-choice questions targeting concepts in biology (11 questions) and chemistry (nine questions).
This target concept needs also to be expressed in terms of representations one already possesses.
This evidence base needs to be represented and rationally tied to the target concept.
