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The expected results should allow to define the position of FTIs as anticancer drugs, particularly in combination with conventional chemotherapy, hormone therapy, radiotherapy or any other new targeted compound.
Its association with the mucus layer and ability to produce outer membrane vesicles can be harnessed for targeted compound delivery.
The differentially expressed proteins can be targets for validation and efficacy testing of future therapies in PXE fibroblasts (targeted compound screening; see above) [ 46].
By 10-fold cross validation, accuracies of our model are around 80%% for most drugs in CCLE, and the highest accuracy of 91.73 % was attained for a pathway targeted compound, the topoisomerase 1 inhibitor Irinotecan.
Targeted compound classes included lipids, amino acids, peptides, proteins, nucleic acids, carboxylic acids and carbohydrates.
And we can create a targeted compound to fight the disease that that mutation causes.
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The structures of the targeted compounds T-1 and T-2 for synthesis are shown in Fig. 2a.
Enzyme-based processes act with high specificity and are very efficient in removing targeted compounds.
The control samples contained DMSO concentrations corresponding to target compound dilutions.
13065_2012_432_MOESM1_ESM.doc Additional file 1: Synthetic route to target compounds 7a-7s.
Scheme 1 Synthetic route to target compounds 7a-7s.
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