Sentence examples for targeted component of the from inspiring English sources

Note that, in drug discovery, the most commonly targeted component of the protein is its hydrophobic binding pocket.

These features have inspired the engineering of CARs able to target components of the EC matrix, such as αvβ6 integrin28 and VEGF receptor-2, usually overexpressed on tumor vessels cells29.

Substantial progress has been made in the development of drugs that specifically target components of the pathways that are associated with these driver mutations.

Pharmacological targeting components of the mitochondrial fusion and fission machineries to normalize normal mitochondrial numbers, morphology, and function may be a novel therapeutic modality for CVD treatment.

Targeting components of the tumor stroma, such as FN, can effectively reduce tumor growth and spread while also enhancing delivery of chemotherapy.

Predictions of pathway deregulation in cancer cell lines are also shown to predict the sensitivity to therapeutic agents that target components of the pathway.

Linking pathway deregulation with sensitivity to therapeutics that target components of the pathway provides an opportunity to make use of these oncogenic pathway signatures to guide the use of targeted therapeutics.

BACKGROUND: Gene expression signatures developed to measure the activity of oncogenic signaling pathways have been used to dissect the heterogeneity of tumor samples and to predict sensitivity to various cancer drugs that target components of the relevant pathways, thus potentially identifying therapeutic options for subgroups of patients.

Many pathogens also target components of the complement system, sometimes taking advantage of existing physiological regulation mechanisms.

These underly numerous anti-cancer strategies targeting components of the core cell death machinery to promote tumor cell death [21], [22].

The N1L protein is a known virulence determinant of VACV [13], [14] that functions by targeting components of the IKK complex to inhibit NF-kB and IRF3 activation [15].