The chairman of a mosque targeted by multiple petrol bombs, has described the attack as attempted murder.
FIXa activity has been targeted by multiple modalities, including oral inhibitors, RNA aptamers, monoclonal antibodies and synthetic active-site-blocking competitive inhibitors.
Our results suggest that DIII is targeted by multiple type-specific antibodies with distinct neutralizing activity, which provides a path for developing prophylactic antibodies for use in pregnancy or designing epitope-specific vaccines against ZIKV.
Tissue-specific expression levels were averaged in case of genes targeted by multiple probesets.
Some host genes were predicted to be targeted by multiple viral siRNAs at distinct locations within the gene.
We found that versican 3'UTR is targeted by multiple miRNAs, which have common targets such as Rb1 and PTEN.
These findings revealed that one miRNA can regulate multiple target genes, and one gene can be targeted by multiple miRNAs.
Reciprocally, a given mRNA can be targeted by multiple miRNAs that differ only slightly in their sequences and, as such, derive from members of a MIR multigene family.
This is a challenging task, since a single miRNA can regulate numerous targets and a single gene can be targeted by multiple miRNAs.
In fact, at least seven gene or domain families (encoding MYB, PENTATRICOPEPTIDE REPEAT (PPR), AUXIN RESPONSE FACTOR (ARF), AGO, F-box domain, kinase and LAC proteins) are now known to be targeted by multiple miRNA families [11].
In addition to the abovementioned GSK-3β, C/EBPβ is also targeted by multiple protein kinases including protein kinase A, calmodulin-dependent protein kinase, Erk-1/2, ribosomal protein S6 kinase, and CDK2 [44].
