Sentence examples for targeted by methylation from inspiring English sources

Methylation specific-multiplex ligation-dependent probe amplification analysis of 29 tumour suppressor genes potentially targeted by methylation resulted in the identification of 12 methylated gene promoters in cervical carcinomas, eight of which could subsequently be associated with consecutive stages of HPV-mediated transformation in vitro.

This finding is consistent with the way the genes were chosen and supports the idea that most of them are targeted by methylation in a carcinogenic process.

Transposons per se are not targeted by methylation in the C. intestinalis genome [ 24].

In addition, genes targeted by methylation were enriched for particular biological processes that differed from those in relatively unmethylated genes.

In vertebrates, TEs are globally methylated, as is the rest of the genome, which makes it less clear whether TEs are in fact specifically targeted by methylation [ 114].

In addition, since the WTH3 promoter's p53-binding site was located in a CpG island that was targeted by methylation, we were interested in testing the possible effect this epigenetic modification had on the p53 transcription factor relative to WTH3 expression.

This mechanism may explain why broadly expressed genes are subject to the highest levels of methylation in invertebrates: broadly expressed genes may be preferentially targeted by DNA methylation due to enhanced negative effects associated with alternate promoters at such loci.

However, 93% of orthologous genes methylated in the fire ant were also targeted by DNA methylation in the honey bee (table 1).

Methylation is important in the development of OSCC and many tumor suppressor genes targeted by promoter methylation will by no doubt be described in the future.

H3.8 is selectively targeted by lysine methylation and by serine or threonine phosphorylation.

Genes with ubiquitous expression among tissues are also preferentially targeted by DNA methylation in both Ap.