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Whatever the effect of the population frequency of HLA molecules on the rate of HIV disease progression is, the current study shows that qualitative differences in the epitopes targeted by different HLA molecules contribute to the association between HLA molecules and the rate of HIV-1 disease progression.
Moreover, whether there are hot-spots on PD-1 or PD-L1 to be targeted by different therapeutic antibodies requires further investigation.
These powerful genomic approaches are recommended by opinion leaders to identify specific pathways that could be targeted by different drugs depending on patients' subset [3].
To assess the specificity of the tool we employed genome re-sequencing to screen for off-target sites in all single knock-out strains targeted by different gRNAs.
For the first few months of his life, Connor is jointly raised by Angel and his team, including Wesley and Cordelia, though he is constantly targeted by different factions.
We also observed that the CCAAT binding transcription factor At1g54160 is targeted by different mature miRNAs (1, 4, and 5).
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The dashboard also shows them current sales, average sales for competitors, conversion rates, and helps them target by different age, income, location, whether they are new or existing customers, and other factors.
The regional variation of PrPres glycoform ratio demonstrated in this study may be of interest in the understanding of "lesion profile" and brain targeting by different prion strains.
These observations resulted in the design of additional experiments developed to examine the immune responses targeting by different autologous HMEC.
Reporter-gene imaging is an indirect approach to labeling cells for image-based in vivo tracking and targeting by different modalities.
Previous studies and this study collectively suggest multiple phosphorylation sites in long PIN-HLs, divergent functions of conserved phosphorylation sites among different PINs, and differential targeting by different AGC kinases.
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