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Because the targeted attributes involve only the contact zone, only events that specifically influence those behaviors are represented.
To narrow the scope and to achieve one of the key targeted attributes, we insisted that CELLS only acquire and use information available locally.
In sequence, we used the list of targeted attributes to falsify and revise these axioms, until the analogue exhibited behaviors and attributes that were within prespecified ranges of those targeted, thereby achieving a level of validation.
As specific information becomes available, it can be added to the set of targeted attributes to stimulate additional rounds of mechanism refinements.
To that end, we have created, studied, and improved quasi-autonomous AT II cell-mimetic analogues that exhibit the identified attributes in Table 1, while adhering tightly to the small set of axiomatic operating principles illustrated in Figs. 3 and 4. Achieving the targeted attributes along with envisioned, future uses and capabilities dictated model design and implementation.
It was improved iteratively using the following protocol: 1) select a new attribute from the list; 2) determine if the current analogue validates against the expanded target list, and if so, go back to step 1; 3) else, iteratively revise the analogue until the measured attributes are sufficiently similar to the expanded set of targeted attributes.
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Once that was achieved, that early SMS was valid for that one targeted attribute.
In order to mimic that important biological reality and to preserve a clean separation between mechanism and phenomena we added a key targeted attribute to the list: CELLS must use only local mechanisms (the third attribute in Table 1).
If narrowing these discrepancies is deemed among the important issues to be addressed next, then our approach would be to include that specification within the targeted attribute list in Set C of Table 1.
Todacell's optimization technology works by taking into account the potential targeting attributes of a campaign, such as publishers, creative, device, location, geo-targeting and demographic, and figures out where the campaign is working best.
In addition, an enhanced cellular internalization of HA-LIPO in CD-44 positive HT-29 and colo 320 cells indicates the targeting attributes of the hyaluronan coated liposomes.
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