Sentence examples for targeted alterations from inspiring English sources

We are confident that with a suitable model, researchers and clinicians will be able to harness the stream of sequence data and begin designing strategies to make targeted alterations to the microbiome and improve health.

We used OPEN to construct 37 highly active ZFN pairs which induced targeted alterations with high efficiencies (1%–50%) at 11 different target sites located within three endogenous human genes (VEGF-A, HoxB13, and CFTR), an endogenous plant gene (tobacco SuRA), and a chromosomally integrated EGFP reporter gene.

Another sigma ECF, sigK, mediates targeted alterations in bacterial transcription via transduction of extracellular signals.

This suggests that targeted alterations to the composition of pyrolysis products may be feasible.

Ultimately, research should strive to find ways to disrupt both processes through targeted alterations in the activity of the plasticity of the involved circuits.

The non-transformed murine fibroblast NIH3T3 cell line has been used for many years as a standard assay for the ability of either chemicals and/or targeted alterations of gene expression to induce cellular transformation (Rubin and Xu, 1989).

Using a gene-targeting vector with promoter trap design, targeted alteration of one allele of KRT14 occurred in 100% of transduced cells and transduction frequencies ranged from 0.1 to 0.6% of total cells.

The ability of unmodified SS ONs to mediate targeted alteration of the mitochondrial genome may provide a new tactic for treatment of certain mitochondrial-based diseases.

Blind spots remain, especially at intermediate length scales spanning a few nucleosomes, but thanks in part to new technologies that permit targeted alteration of chromatin states and time-resolved studies, the next decade holds great promise for hypothesis-driven research into the mechanisms that drive genome architecture and transcriptional regulation.

Future research may need to target alterations at the posttranslational level to obtain a more comprehensive picture of the cellular response.

Targeted alteration (knock-in) of the Htr2c gene to generate 'INI' mice with no alternate splicing, solely expressing the full-length unedited isoform, did not produce an overt metabolic phenotype or altered anxiety behaviour, but did display reduced depressive-like and fear-associated behaviours.