Sentence examples for targeted alignment from inspiring English sources

This method should be less sensitive than targeted alignment, because the version of GSNAP we used requires 14 nt on each side of an exon-exon junction to identify a spliced alignment, rather than the 8 nt we used for targeted alignment.

But for intergenic splicing events in general, targeted alignment is not applicable as a computational strategy, because it is infeasible to generate all possible exon-exon pairs over the human genome.

In this paper, we show that both the targeted alignment and spliced alignment approaches can be used in complementary ways to study TICs and gene fusions in individual cancer and normal samples assayed by deep transcriptional sequencing.

Optimized for speed of aligning reads to the entire genome, such full-text indexing is unnecessarily demanding in memory usage and requires online reconstruction of the suffix array, when compressed, for targeted alignment.

Although spliced alignment is less sensitive than targeted alignment, it does have the ability to find novel splicing at locations not included in a database of known splice sites.

What makes targeted alignment feasible for the universe of TICs is the constraint that the splice sites lie within 200,000 bp, which limits the number of exon-exon junctions to 2.5 million, a small fraction of the total set of possibilities.

These ranges were established based on reported surgical precision for achieving targeted component alignment [ 10, 15, 16] and the magnitude of deviation from optimal alignment that has been associated with clinical and biomechanical complications [ 18, 20, 31- 34].

The target alignment in arthrodesis of the knee was neutral rotation, flexion of 10 15 degrees and valgus of 7 10 degrees.

Specifically, a kernel target alignment approach has been considered as the fourth ranking method (it will be called KA for future references) [28].

With increased precision in alignment offered by new generations of instrumentation and customized guides, this study was designed to establish a biomechanically-based target alignment for the balance of tibial loading in order to diminish the likelihood of pain and subsidence related to mechanical overload post-UKA.

Therefore, CQI entails the careful monitoring of service processes and outcomes in terms of necessary inputs (e.g., resources, tools, financial investments), outputs (e.g., service number targets, alignment of services with client needs), and outcomes (e.g., program effectiveness, sustained client impact).