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Trabectedin, bendamustine and the pyrrolobenzodiazepine dimer SG2000 exemplify three different classes of DNA targeted agent undergoing clinical evaluation.
Nearly every effective targeted agent has a biomarker that can predict response.
It is important to develop methods that more accurately assess efficacy of cetuximab in patients with incurable SCCHN since this costly targeted agent benefits a minority of patients.
Targeted agent development needs to be customized to address these cancers or cancer subtypes uniquely prevalent in Asia Pacific.
While these results support utilizing RAS mutation status to direct choice of first-line targeted agent, further phase III data are required to establish the optimal first-line targeted agent in the all- RAS-WT population.
Positive clinical outcomes, obtained using the targeted agent trastuzumab, suggest that the surface antigen HER2 may serve as a target for CAR-T cell therapy.
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Although AKR1C3 is a promising drug target, no AKR1C3-targeted agent has to date been approved for clinical use.
We demonstrate that medulloblastoma cell lines express IL-4R that serve as a sensitive target for IL-4R-targeted agent, cpIL4-PE.
FDG PET may also show an early response to the HER2-targeted agent lapatinib [14].
No AKR1C3-targeted agent has to date been approved for clinical use.
These positive results support the progress of a low cost multi-targeted agent with putative roles in diabetic complications.
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