Sentence examples for targeted activation of from inspiring English sources

Spatially targeted activation of PtIV prodrugs using light is also a promising approach.

Here we report a transcription factor decoy strategy for targeted activation of eight large silent polyketide synthase and non-ribosomal peptide synthetase gene clusters, ranging from 50 to 134 kilobases (kb) in multiple streptomycetes, and characterization of a novel oxazole family compound produced by a 98-kb biosynthetic gene cluster.

Taken together, these results demonstrate that dsVHL-821, a novel saRNA for VHL, induces the expression of the VHL gene by epigenetic changes, leading to inhibition of cell growth and induction of apoptosis, and suggest that targeted activation of VHL by dsVHL-821 may be explored as a novel treatment of renal cell carcinoma.

The two-way selection this provided allowed targeted activation of the receptor upon ligand binding.

These results suggest a targeted activation of pertussis specific CD8+ T cells after vaccination.

Rather than targeted activation of the core pluripotency circuit by defined factors, this approach may be thought of as giving a non-specific "shake" to the system in order to realign it to the pluripotent ground state.

Man, S. M. et al. The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.

An osteoclast progenitor cell-based high-throughput screening system was designed to target activation of NFAT, which is a key event for osteoclastogenesis.

We contend that coevolution of Nrf2-activating secondary metabolites by fungi and other extant microbiota may provide prospective compound leads for the design of new therapeutics to target activation of the human Keap1 Nrf2 pathway for treating degenerative diseases of ageing.

Dedicated pairs of isometric wrist flexion tasks, with and without visual feedback of the exerted torque, were designed to target activation of the CBL and BG in healthy subjects during functional magnetic resonance imaging (fMRI).

Targeting activation of mast cells to prevent release of mediators represents an important treatment alternative [ 20, 39, 52, 53].