In Chemoinformatics and Computational Chemical Biology, leading investigators bring together a detailed series of reviews and methods including, among others, system-directed approaches using small molecules, the design of target-focused compound libraries, the study of molecular selectivity, and the systematic analysis of target-ligand interactions.
To facilitate the construction of target-focused libraries for virtual screening, we developed eSynth, a new fragment-based approach to molecular synthesis that follows simple combinatorial chemistry steps using an optimized, graph-based algorithm.
We applied the KLS (Equation 1) to make a target-focused library for kinases.
Target-focused libraries are either designed or assembled upon some understanding of a specific protein target or a protein family.
Launching a campaign is incredibly demanding and stressful, and creating running dialogue with backers essential -- you'll save yourself a world of hurt by taking a more focused approach to audience targeting, and not having to scramble at the last minute.
Both of these targets are in clear competition with Harper, whose militaristic and security-focused approach have been staples during his campaign.
We believe that in the future, Twitter can target sustainable growth by positioning itself along one (or more) of three strategies: by adopting a content-focused approach, a news-focused approach or a data-focused approach.
This represents a problem-focused approach to chemicals management.
Philanthropists often have a more focused approach: they want specific results and quick proof.
This makes sense when you consider Telltale's dialogue-focused approach to gameplay.
For this President Bush, a more focused approach is a familiar strategy.
