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Drug molecules designed along those principles are usually rigid and unable to adapt to target variations arising from naturally occurring genetic polymorphisms or drug-induced resistant mutations.
The films were grown in two target variations.
More advanced pipelines avoid exposing stalls from the ISA in order to avoid too many (compiler) target variations and retain binary compatibility between processor versions.
Evaluation showed that miRNA-centric μ measure exhibited the best specificity and homogeneity except only for the target variations #12, #19 and #22.
50% of off target variations (n=1,291), in fact, were not called in the scout pools and were easily filtered off during bionformatic analysis.
Because of the small numbers of miRNA members and target genes, target variations #5, #10, #11, #15, and #16 in Table 1 had no significant GO terms.
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They also determined how many copies, if any, the children carried of the target variation.
[7] Still, this corresponds roughly to leaving out a single target out of 14 in the NNRTI set (+/− 10% of target variation).
Another advantage of the use of oligodeoxyribonucleotides as targets is that we can analyze the specificity of single nucleotide mismatches without effects of target variation, such as variations in target length due to random fragmentation [ 15, 16].
a The 'breast/up-regulated' miRNA cluster data from Volinia et al. (2006) using the target variation #6 (see Table 1) was used.
The input format for this section comprises 5' and 3' flanking sequences or a target variation, which is described in IUPAC or bracketing format.
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