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THE death toll was shocking, the target unexpected, the deed itself monstrous.
This task included expected and unexpected nonrewarding events (expected target, unexpected nontarget, and omission of target) in a design that closely parallels studies of dopamine function and reward processing in the alert monkey.
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There were no "off-target" unexpected complications identified in the primary publications of any of these RCT that could have explained the excess mortality of the intervention arms.
But the target was unexpected.
Stores like Kohl's that master this new format will give discount titans like Wal-Mart and Target an unexpected run for their money.
As such a low number of targets was unexpected, we analyzed the individual read counts of candidate target genes in order to test whether these genes were missed in either treatment because they are synergistically regulated (supplementary material Fig. S3B).
Seizure-suppressor genes could help define targets for unexpected classes of anticonvulsant drugs that are effective treatments for epilepsy: treatments for intractable syndromes or treatments with reduced side effects.
The ability of NKX2-5Y191C aNKX2-5∆HD∆HD to bind a large number of targets was unexpected.
Motivation: Analysis of relationships of drug structure to biological response is key to understanding off-target and unexpected drug effects, and for developing hypotheses on how to tailor drug therapies.
The recent floods are devastating large parts of the UK have been put down to a variety of reasons, but one government adviser has, by some interpretations, taken aim at an unexpected target – TV garden shows.
These include "Off-target" adverse effects caused by a drug binding to an unexpected target and "On-target" adverse effects as a result of a drug binding to its intended target that is not only present in tumor cells, but also found in normal tissue [ 26].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com