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As discussed in [38], the TT residuals can be artificially increased due to several factors including small differences in calibration, resolution, and spectral noise among samples and models at different beamlines or data collection periods, and correlation between targeted vectors due to the oblique rotation inherent in target transformation.
In this study, neural network models were constructed that successfully classified the targeted bacteria and the classification model was validated using sensitivity and target transformation factor analysis (TTFA).
target transformation.
A linear combination fit constrained by target transformation is a model-dependent analysis--that is, the results obtained depend on the models chosen for fitting.
A discussion on LCF illustrates the importance of choosing standards based not only on statistical methods such as Target Transformation but also on sample mineralogy and particle size.
Principal component analysis (PCA) and target transformation identified six standard compounds suitable for the fitting of Ag in sludge samples: Ag2S NPs, Ag-acetate, Ag-glutathione (Ag-GSH), Ag-thiosulfate, Ag-foil (Ag0) and Ag2S (Figure 4).
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Normalized, k3-weighted EXAFS spectra [χ k)*k3)] of As model compounds tested in PCA target transformations and used in non-linear least squares fits.
Target transformations (TT) employing only the principal components from group 1 (n = 4) and group 2 (n = 2) were performed to identify the appropriate model spectra to be used in LC fits.
This is in contrast to transformants that are obtained by targeted transformation approaches or mutants obtained by insertion mutagenesis.
The resulting effects on regulation of transgene expression and the cell-to-cell variability in transformed lines, even after cloning, provide strong incentives to adapt targeted transformation techniques for cell lines.
Together with an adaptive design framework, we show that iteratively learning and improving the statistical model can accelerate the search for SMAs with targeted transformation temperatures.
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