In 1975, working with Köhler, who was a postdoctoral fellow at Cambridge, Milstein developed one of the most powerful tools of molecular biology: monoclonal antibody production, a technique that allows researchers to construct cells that produce great quantities of identical (monoclonal) antibodies, all targeted to recognize the same antigen.
Therefore, these studies collectively provide robust evidence that PBD-phosphopeptide binding is essential for PLK-1 targeting to recognize the substrate and also regulate the PLK-1.
Likewise, the analysis of proteins, their post-translational modifications in normal and pathological conditions, coupled with the development of highly specific antibodies targeted to recognize different forms and states of proteins, including antibodies that work inside living cells (Attreed et al., 2012), will play pivotal roles in deciphering the molecular mechanisms of lens development.
NK cells do not need previous exposure to their target cells to recognize, bind to, and destroy these targets (e.g., cancer and virus-infected cells) (Vivier et al. 2008).
Furthermore, at closing, Target expects to recognize an additional pretax gain of $350 million to $450 million on the sale of its portfolio.
Macromolecular construction "DPDPB GST tag-GEC1 protein" was conceived in order to guarantee a 2D architecture enhancing the capabilities of the target (tubulin) to recognize its partner (GEC1).
The resulting binary T F masks are used by an uncertainty decoder and a target selection mechanism to recognize the target utterance.
This instrument uses probes with two dyes on opposite ends of a target sequence oligonucleotide to recognize SNP polymorphisms.
Very different results may be seen if a certain secondary/tertiary structure were the target to be recognized by the replicase, but the present modelling techniques are not sufficient, so we have to accept the 'toy' approach of the authors.
The main component of RISC is Argonaute protein which facilitates the binding of miR-RISC to the target mRNA by guiding RISC to recognize the target mRNA having complementary sequence to perform gene silencing.
