Tony Smith, chief executive of the Consumer Council for Water, said: "Ofwat's approach to setting leakage targets needs to recognise customers' perception that water companies are not doing enough about their leaky pipes.
But Tony Smith, the chief executive of the Consumer Council for Water, said: "Ofwat's approach to setting leakage targets needs to recognise customers' perception that water companies are not doing enough about their leaky pipes.
US lead negotiator, Todd Stern, echoed the call for the 1.5-degree target to be recognised in the eventual agreement.
The complexity of the NK cell compartment is attributable to the vast network of receptors that are expressed on NK cell surfaces, which allow them to recognise target cells.
Serotype specific clones showed intermediate (D9, 10A4 and 3H9) activity against their cognate peptides (pD3/4, pD2, pD2 respectively) but failed to recognise target cells pulsed with the peptide variants (Fig 3c).
It is widely assumed that CHD is caused by haploinsufficiency and an inability of mutant proteins to recognise target genes.
We hypothesise that the polyclonal antibody recognises an active form of PODXL at the cell membrane, whereas the monoclonal antibody with its smaller target epitope is able to recognise overexpression of cytoplasmic PODXL, that either has a function in the cytoplasm, or is moving towards the cell membrane.
Finally, when assessing targets it is important to recognise that complete success is unrealistic.
For instance, tumour infiltrating lymphocytes capable of killing autologous bladder tumour cells in 2D, failed to recognise targets when cultured in 3D (Dangles et al, 2002).
Modulation of MHC expression on tumours is possible; however, in the light of these observations, targeting of T cells to recognise intact cell surface protein antigens using antibody-based technologies, thereby avoiding tumour antigen presentation mechanisms, has been the focus of an increasing number of research groups.
Most vaccines are used to prevent infection, but therapeutic cancer vaccines aim to treat disease by stimulating the immune system to recognise and target the cancer.
