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Based on the aforementioned evidence, we hypothesized that the lateral hypothalamus was the logical target to induce manic-like behaviors.
These constructions include bispecific CAR-T cells, which can be activated only by the identification of both CAR molecules (Wilkie et al., 2012), and the synNotch circuit, in which T cells are armed only by a synthetic Notch receptor activated by one target to induce the expression of a CAR against another target (Roybal et al., 2016).
Our results point towards modulation of CRMP-2 activity as a therapeutic target to induce axonal regeneration.
After incorporation into RISC, the processed siRNA is loaded onto an mRNA target to induce either mRNA cleavage by Ago2 or translational repression and subsequent mRNA degradation.
The V3 region of HIV-1 gp120 is an important target to induce neutralizing antibodies against different strains of HIV-1.
Furthermore the demonstration that ERRα can regulate expression of human UCP1 expression in these cells suggests that increasing ERRα activity may be a viable therapeutic target to induce UCP1, and hence increase uncoupling as a potential therapy for obesity.
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Therefore, cofactors are emerging to be attractive targets to induce widespread changes in metabolism.
The harder charge modulation makes it more difficult for the DNA targets to induce an electrical signal.
Both peripheral and central nerve terminals at the spinal cord can be targeted to induce pain relief by TRPV1 agonists.
Future vaccine designs might therefore be targeted to induce strong antigen-specific Tfh responses in order to boost its protective effects.
We conclude that other pre-erythrocytic parasite antigens, possibly hitherto uncharacterised, can be targeted to induce sterile immunity against malaria.
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