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Therefore, its inhibition has become an attractive target to develop new therapies against this disease.
Recently, a broad interest pointed to cancer metabolism as a promising target to develop new therapeutic approaches.
"Ultimately, we hope we find genetic hits that point the way to the biological systems that we need to target to develop new treatments.
Plasmepsin, an aspartic protease, which is involved in the hemoglobin breakdown into smaller peptides emerged as a crucial target to develop new chemical entities to counter malaria.
Hemozoin formation is a validated target for most of the well-known existing antimalarial drugs and considered to be a suitable target to develop new antimalarials.
Among the many signaling pathways involved in maintaining GSC stemness, tumorigenic potential, and anti-apoptotic properties, the PDK1/Akt pathway is a challenging target to develop new potential agents able to affect GBM resistance to chemotherapy.
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The analysis aims to pinpoint key changes in the host response to viral infections that may be targeted to develop new anti-influenza therapeutics.
The researchers suggest the enzyme and others in the l-lysine pathway could also be targeted to develop new antibiotics and herbicides.
Those genes associated with ANM could be used as targets to develop new drugs aimed at delaying the end of the reproductive capacity in women by, for instance, preventing premature depletion of the ovarian pool of oocytes.
The interest in nAChR target screening to develop new veterinary and pesticide products [9] parallels our success in reducing cyst nematode invasion of plants by expressing the levamisole mimetic peptide in their transgenic roots [10].
Several prognostic markers exist, and recent studies have indicated promising new targets to develop novel strategies for systemic therapies in endometrial cancer (Salvesen et al, 2009).
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CEO of Professional Science Editing for Scientists @ prosciediting.com