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It is expressed in villous cytotrophoblasts (vCTBs), promotes proliferation and survival of trophoblastic cells and is a promising target to decipher the molecular mechanisms behind the pathogenesis of PE in more detail.
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It successfully applied varying dinucleotide density profile with respect to putative target positions to decipher the role of flanking region in miRNA targeting in animal system.
Altogether such signal can serve as a target for biologists to decipher its regulation role by experiments, thus leading to a better understanding of the initiation mechanism.
Currently, bioinformatics methods have been used to decipher target genes in several studies [ 47, 48].
To this end, we used Target Scan and Ingenuity Pathway Analysis to decipher the predicted targets and pathways for the age-associated oncomirs/ts-mirs identified in our study.
This structural conservation of motifs also suggests that motif regions of sRNA could be structurally or functionally important regions and can be used as targets for mutational studies to decipher function.
Despite these advances, the extraordinarily complex cellular responses to MYC expression has made it difficult to decipher the target genes that mediate these biological activities.
Future examination of these and other FruM target genes will allow us to decipher this code and connect specific dimorphic neural cell fates with behavioral outputs.
Liver was chosen as a target tissue of the LPS to decipher the role p8 in constitutive gene expression and in the response to LPS.
To decipher specific targets for treatment, it is important to develop an improved understanding of the molecular changes that contribute to the transition from paroxysmal to persistent AF.
To decipher any off target effects, a second NET1 siRNA duplex was used with the following sequence: sense, 5′-GGUGUGGAUUGAUUGGAAA-3′; antisense, 5′-UUUCCAAUCAAUCCACACC-3′. The effect of RNAi on cell viability was assessed using flow cytometry by staining with propidium iodide and Annexin V FITC.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com