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Fused glass beads of rock samples could be an adequate target to circumvent this problem.
This gene may constitute a better target to circumvent this limitation but this gene is not directly linked to the sulfide oxidation process and this may explain why many pufM-related sequences belonged to bacteria which were not able to use reduced sulfur compounds (i.e., PNSB).
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Taken together, our study supports the hypothesis that MET may be targeted to circumvent T790M-EGFR-mediated intrinsic or acquired resistance to EGFR-TKI (erlotinib) in lung cancer.
We also highlight the evidence supporting the use of miRNAs as biomarkers for response to anti-EGFR agents and as novel therapeutic targets to circumvent the resistance of lung cancer cells to EGFR inhibitors.
This strategy enables to detect weak targets and to circumvent the data association problem originating from the detection stage of classical radar systems.
Advances in antibody engineering technologies have enabled strategies that simultaneously target multiple receptors to circumvent the limitations of conventional monospecific therapies and achieve enhanced therapeutic efficacy.
In order to assess Wnt transactivation, we used endogenous Wnt target gene expression (to circumvent artifacts associated with transfection of highly refractive primary cells).
This review highlights the various potential MD approaches for the simulation of CNT interactions with cell membranes while emphasizing various methods of cellular internalization and toxicities of CNTs to build new strategies for designing rational CNT-based targetedrugug delivery to circumvent the limitations associated with the various clinically available nonspecific therapeutic agents.
The therapeutic listing of the conservative or gene-based drugs (e.g., plasmid DNA or RNA transcripts) are enhanced by delivering more biologically active drug to target cells or tissues, to circumvent drug-related toxicities.
Recently, it has been characterized the tumorigenic role of Fas/FasL in cholangiocarcinoma and it has been suggested this pathway as a potential molecular target for therapeutics strategies to circumvent apoptosis-resistance of cholangiocarcinoma cells[ 27].
Thus, their great potential lies in the ability to attach specific targeting peptides to plasmids to circumvent such barriers to gene transfer as cell-targeting or nuclear localization, thereby increasing the efficacy of gene therapy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com