CSB and XPA may represent rational targets to augment cisplatin responsiveness of tumours, independent of MMR capacity and p53.
TCGA analysis also showed that immunosuppressant proteins currently being evaluated as targets to augment antitumor immune response, such as programmed death ligand 1/2 (PD-L1/2), were elevated in EBV-positive tumors, suggesting that PD-L1/2 antagonists represent new therapeutic options for the EBV subtype of gastric cancer.
Furthermore, MSC can be functionalized with targeting moieties to augment their homing toward therapeutic sites using enzymatic modification, chemical conjugation, or non-covalent interactions.
Clinical application of the PARimpact scale should be considered to identify high-risk families and provide targeted interventions to augment care.
Here we have demonstrated that Grp58 appears to regulate WNT signaling by targeting β-catenin to augment cancer invasion.
There are numerous experimental data both in vitro and in vivo showing that EGFR targeting is able to augment the antitumour activity of several anticancer agents including doxorubicin, cisplatin, 5-fluorouracil (5FU), gemcitabine, paclitaxel and topotecan (Baselga et al, 1993; Fan et al, 1993; Ciardiello et al, 1999; Bruns et al, 2000; Inoue et al, 2000; Overholser et al, 2000).
Some, like Target Tracker, were meant to augment attention.
Any strategy that attempts to target the Wnt pathway to augment tissue regeneration will have to take into consideration the need to selectively and locally activate signaling in the tissue or area of interest, whilst simultaneously restricting Wnt signaling in other parts of the body.
Although computational docking of ligands to targets has been used to augment the empirical discovery process, its historical effectiveness has been limited because of the poor correlation of ligand dock scores and experimentally determined binding constants.
It is also possible to enhance the EPR effect by utilizing active tumor targeting, or coadministering agents to augment tumor vasculature and blood pressures.
