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While several HIV drugs target the virus effectively, there has not been a new class of HIV drugs approved to combat the disease in a decade.
New drug candidates designed to target the virus or the host have recently been introduced at an unprecedented pace.
Towards this goal, we constructed and characterized an oncolytic adenovirus, carrying mutated capsid proteins to abolish the promiscuous adenovirus native tropism and encoding a bispecific adapter molecule to target the virus to the epidermal growth factor receptor (EGFR).
Reliable diagnostic systems that can rapidly identify the BTV type(s) circulating in a region and/or those involved in an outbreak are necessary for the design and implementation of appropriate control strategies that target the virus strains involved.
Unlike the drugs used in HAART, which target the virus, minocycline homes in on and adjusts T cells, major immune system agents and targets of HIV infection.
Gene therapist Mark Kay and his postdoctoral student Anton McCaffrey, both of Stanford University in California, and their colleagues wanted to know whether RNAi could target the virus behind hepatitis directly--the only way to ultimately cure people of the disease.
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In order to limit the consequences of infections with flaviviruses, a promising approach consists in developing specific compounds that target the virus-encoded NS2B/NS3 protease complex, which is crucial for the viral polyprotein processing.
This Clinical Trial Watch summarizes the most recent therapeutic strategies designed to directly target the viruses B and D or to improve immune responses during chronic HBV infection.
Drugs to block Il-6 might be one therapeutic avenue, and Berenson also suggests that it might be possible to devise therapies that specifically target the virus-infected dendritic cells themselves.
Salzwedel, K., Martin, D. E. & Sakalian, M. Maturation inhibitors: a new therapeutic class targets the virus structure.
Antiviral therapies targeting host genes that the virus depends on, rather than targeting the virus itself, are promising because these genes do not mutate as frequently as viruses do.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com