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For common diseases, the observed small effect sizes of individual gene variants limit diagnostic potential, and given that most variants identified have an unclear function, how to target the corresponding gene for therapeutic intervention is typically unclear.
A consensus PPMO (designated Noro 1.1), designed to target the corresponding region of several diverse human norovirus genotypes, decreased the efficiency of protein translation in a cell-free luciferase reporter assay and inhibited Norwalk virus protein expression in replicon-bearing cells.
It follows therefore that suffix-specific siRNAs could potentially target the corresponding transcripts and give rise to silencing of these genes in some cell types.
Another green box contain the miRNAs which target the corresponding genes in the function is attached to the red one.
To target the corresponding specific apple element, each single CDS sequence was blasted on the apple geneset available in the Rosaceae database (www.rosaceae.org).org
By defining a more suitable distribution of end wall velocity as the design target, the corresponding end wall geometry can be solved from the equation system and is expected to modify the end wall flow as the design target.
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Furthermore, although expression of pro-inflammatory chemokines (CCL2, IL-1α, TNFα) was induced in spheroid formation, compounds targeting the corresponding receptors proved ineffective.
For example, if a gene's deletion causes hypersensitivity to an antibiotic, that antibiotic and a drug targeting the corresponding gene product may act synergistically.
Positive correlation between protein connectivity (degree in PPIN) and the number of miRNAs targeting the corresponding protein has been observed by Liang and Li [ 32].
We therefore investigated the contribution of each UPR branch to CHOP gene induction by using small interfering RNAs (siRNAs) targeting the corresponding UPR transcription factors.
Each ssODN was co-injected into w embryos with a pDCC6 plasmid that targets the corresponding gene close to the stop codon (File S1).
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