Haploinsufficiency of fibrillin-1 [8], [8] markedly changes the extracellular targeting, sequestration and turnover of latent TGFβ, resulting in pronounced activation of the growth factor and the signaling pathway [4], [5], [9].
Absence of CD36 as a target for sequestration on these large capillary beds may promote splenic passage and clearance of CD36-binding parasites.
MiRNA-mediated gene regulation involves binding to the 3'-UTR of their mRNA target and sequestration of mRNA by the miRNA/RISC complex (RNA-induced silencing complex ) in the cytoplasmic processing bodies, which results in repression of translation initiation or mRNA degradation reviewed in [ 2].
The current repression models of the mechanisms of miRNA-mediated gene silencing are still the subject of considerable debate [ 21], and many potential targets may actually be pseudotargets, thus preventing miRNAs from binding to their authentic targets via sequestration [ 22].
The Derived Guinea Savannah presents a potential hotspot for targeted carbon sequestration projects in Nigeria.
Oil fields offer a significant potential for storing CO2 and will most likely be the first large scale geological targets for sequestration as the infrastructure, experience and permitting procedures already exist.
Highly branched β-1,3-glucan matrix in C. albicans single-species biofilms has been shown to prevent drugs from reaching their own cellular target through drug sequestration in vitro.
A favored target for subsurface sequestration is clastic reservoirs, due to their limited tendency to impact water quality or porosity and permeability due to dissolution or precipitation compared to carbonate reservoirs.
On several occasions, the White House has presented a comprehensive, specific package of spending cuts and tax loophole reforms that easily meet the sequestration target of $85 billion in deficit reduction over 10 years.
(1) VCAM-MPIO detected VCAM-1 expression and defined its 3-dimensional distribution, revealing "ischemic memory" in renal IRI; (2) automated volumetric quantification of VCAM-MPIO accurately reflected tissue levels of VCAM-1 mRNA; and (3) VCAM-MPIO bound rapidly to target with active sequestration of unbound MPIO in the liver and spleen.
