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Visit 3 will occur on a participants target quit day (17 days after enrollment).
The median time to the first cigarette smoked after target quit day was 15 days in both groups (interquartile range 13-18 in the nicotine patch group, 13-20 in the placebo patch group).
The final study visit (Visit 5) will occur 28 days after participants target quit day.
By week 2 after target quit day, 62% of the women had relapsed; the median time to the first cigarette smoked after target quit day was 15 days in both groups (fig 2).
A pragmatic randomized control trial on 1100 adult smokers revealed that using NRT 2 weeks before the target quit day was safe and well tolerated but offered no benefit over usual care.
18 This study had high attrition in both groups and greater attrition earlier in the naltrexone group: 10 people in the naltrexone group and 2 people in the placebo group were considered treatment failures because they dropped out prior to the target quit day.
Similar(53)
The target quit date was day 15.
The primary outcome was carbon monoxide confirmed abstinence from weeks 5 52 following a target quit date.
Interventions Interventions began one week before a target quit date.
Smoking status was confirmed biochemically and via self-report at quit day and each follow-up assessment.
Participants will be instructed to quit smoking completely on their assigned quit day.
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