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The primary outcome was carbon monoxide confirmed abstinence from weeks 5 52 following a target quit date.
The target quit date was day 15.
In this trial, 369 European-American smokers were randomized to 21 or 42 mg NRT, initiated 2 wks before target quit dates.
INTRODUCTION: Previous studies have reported that smoking abstinence rates are increased when nicotine skin patch treatment is initiated prior to the target quit smoking date, as compared with conventional treatment beginning on the quit date.
Five immunizations with Nicotine-Qβ were administered at months 0, 1, 2, 3 and 4. The target quit date was set to month 1 and smoking cessation counseling started at week 3 and was performed until month 4. Of the 340 subjects in the intention-to-treat population, 229 received the vaccine and 111 the placebo.
Interventions Interventions began one week before a target quit date.
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24 Self-reported smoking status and exhaled CO level were measured at baseline and every follow-up visit at 3, 6, and 12 months post-target quit date (TQD).
Viewing smoking among women by professional group provides a context for understanding the culture of smoking behavior and supporting targeted quit efforts.
In one study, the initiation of mecamylamine treatment prior to the target quit-smoking date was shown to be critical in promoting subsequent continuous abstinence from smoking.
A "target quitting date" was set at 1 month after the first vaccination.
One possible approach could be to target women who quit smoking during pregnancy and prevent them from resuming to smoke.
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