4. Our formulae deliver justified hypotheses also in the cases that are not as straightforward as the cases in Figure 1(a - b)/Figure 2(a - b), given two additional assumptions, that we call the source principle and the target principle.
The target principle holds that large changes in the target are sucient for a hypothesis regarding startup/shutdown of a stimulation/inhibition, even if the value of the source (the stimulator/inhibitor) is inconsistent.
ACh release from basal forebrain neurons excites layer 1 and VIP+ interneurons, which in turn inhibit local interneurons that target principle neurons of the cortex (Letzkus et al., 2011; Pinto et al., 2013; Fu et al., 2014).
The present review compiles the recent advances in dendrimer-mediated drug and gene delivery to tumors by passive and active targeting principles with illustrative examples.
The stealth effect attributed to PEGylation in liposomes has opened up new horizons in prolonged drug delivery, and proved to be a promising tactic to solve safety issues associated with active targeting principles.
From the data that we have, it is hard to determine if all patients were indeed treated according to the treat-to-target principles.
10 Key features of TeamCare-PCN include coordinated care by a nurse care manager to direct active patient follow-up, treat-to-target principles and specialist (ie, psychiatrists and internists/endocrinologists) consultation.
UNICEF should work together with partners in Niger to promote harmonization of cash transfer initiatives, including targeting principles, definition of amount to be transferred taking into account different household sizes and needs, and monitoring structures.
Since previous hypotheses on the 27 nt-ncRNA targeting mechanism did not seem to hold with regard to current models of miRNA targeting principles, we decided to reinvestigate the underlying mechanisms using an in vitro reporter assay as well as phylogenetic analyses.
These ferrofluids can, e.g., be used for the treatment of cancer, making use of the drug targeting principle or using an artificially induced heating.
These results prove the flexibility of E. coli β-galactosidase as a carrier for large-sized functional domains with binding properties and prompt the further exploration of the biotechnological applicability of the scFv enzyme targeting principle for diagnosis or other biomedical applications involving antigen tagging.
