Sentence examples for target principle from inspiring English sources

The target principle holds that large changes in the target are sucient for a hypothesis regarding startup/shutdown of a stimulation/inhibition, even if the value of the source (the stimulator/inhibitor) is inconsistent.

ACh release from basal forebrain neurons excites layer 1 and VIP+ interneurons, which in turn inhibit local interneurons that target principle neurons of the cortex (Letzkus et al., 2011; Pinto et al., 2013; Fu et al., 2014).

4. Our formulae deliver justified hypotheses also in the cases that are not as straightforward as the cases in Figure 1(a - b)/Figure 2(a - b), given two additional assumptions, that we call the source principle and the target principle.

These ferrofluids can, e.g., be used for the treatment of cancer, making use of the drug targeting principle or using an artificially induced heating.

These results prove the flexibility of E. coli β-galactosidase as a carrier for large-sized functional domains with binding properties and prompt the further exploration of the biotechnological applicability of the scFv enzyme targeting principle for diagnosis or other biomedical applications involving antigen tagging.

Constructs and targeting principle are depicted in Figure 6 A and 6B, respectively.

The 28-joint Disease Activity Score (DAS28) was systematically determined and patients were treated according to the treat-to-target principle, aiming for DAS28 <2.6, using conventional DMARDs, corticosteroids and biologicals, if indicated.

Patients in the usual care group will continue treatment by their own rheumatologist, following a standardized protocol based on the tight control/treat-to-target principle and aiming to maintain low disease activity.

A likely explanation for this effect is that if disease activity remained too high, a step-up in therapy was made following the treat-to-target principle, regardless of unknown underlying non-adherence behaviour [ 3].

The course of the DAS28 over the first year of treatment in our cohort is similar to that of other studies in which patients were treated according to the treat-to-target principle [ 17], which supports our explanation that patients were treated to target.

However, clinical trials of insulins have typically employed a "treat-to-target" principle, whereby instead of examining fixed drug doses, investigators titrate the drugs under investigation to achieve a fixed treatment target; in the case of diabetes trials, this is typically a specific HbA1c target.