These peptides are of low molecular weight, synthetically versatile and inexpensive to produce, suggesting that they can be used as drug targeting, potent, stable and bioavailable agents.
It is quite surprising to see the number of microRNAs that can co-target potent tumour suppressors and oncogenes.
Our data demonstrate the potential risk associated with clinical application of broadly acting covalent epigenetic modifiers, and highlight the value of combination therapies that include agents specifically targeting potent pro-metastatic genes.
A recent study showed that enzymatically modified antibodies can be used to generate highly targeted, potent immune responses.
42 Nevertheless, given that even weak selective pressure against p7 can drive HCV to escape, evidenced by the selection of both Leu20Phe 34 and potentially other polymorphisms, 35 the prospect of employing targeted, potent molecules becomes highly attractive.
This previously unrecognized regulatory region might offer a molecular target for potent and reversible inhibitors of MGL.
Because calcineurin is the target of potent inhibitors in widespread clinical use, cyclosporine and FK506 (tacrolimus), it is an attractive drug target for novel antifungal agents.
HA is the primary protective antigen in licensed influenza vaccines and the target of potent neutralizing antibodies.
Volatile anaesthetics such as isoflurane, have multiple protein targets, are potent cerebral vasodilators and there exists a narrow range of isoflurane concentrations (<1.5 2%) under which neurovascular coupling is preserved35,36,37.
