Sentence examples for target potency from inspiring English sources

The validated range is from 70% to 130% of the target potency of 5.8 × 105 IU/mg.

Substituents on the inhibitor scaffold were varied to optimize target potency, antibacterial activity and in vivo pharmacokinetic stability.

One remaining challenge is how to achieve balance across all CNS preferred physicochemical properties together with optimal target potency.

Higher mass flow rates resulted in first off tablets closer to target potency, a shorter tablet potency startup phase, and greater assurance of passing content uniformity testing.

Introduction of a neighboring fluorine atom or installation of a methylene linker reduced hCA potency sufficiently, at the cost of MEK target potency.

These efforts resulted in a hybrid compound with target potency increased by a 1000-fold, while maintaining selectivity against selected protein kinases and an improved level of solubility and protein binding.

This process guarantees closeness between actual and target potencies, as exemplified by the results of release assays obtained during a three-year period.

Compared with previously established work, the new algorithm was more effective in reducing off-targeting without jeopardizing on-target potency.

Here we describe the application of methotrexate-linked small molecule ligands to a mammalian three-hybrid interaction trap for proteome-wide identification of small molecule targets, quantification of the targeting potency of unmodified small molecules for such targets in intact cells, and screening for inhibitors of small molecule-protein interactions.

Doing so increases the on-target potency of the reaction compared with other approaches.

Furthermore, treatment with concentrations of AT-IAP as low as 10 nM induced cIAP1 downregulation, demonstrating the high on-target potency of this agent.