However, as many carboxylesterases are inhibited by OPs [ 74], the up-regulation of ZC376.3 could also represent an off-target, positive feedback loop (see below).
PLD isozyme acts as a novel transcriptional target and positive feedback regulator of Wnt signaling, and then promotes Wnt-driven anchorage-independent growth of colorectal cancer cells.
In the present study, we demonstrate that PLD isozyme is a novel downstream target and positive feedback regulator of the Wnt/β-catenin signaling pathway.
In the present study, we demonstrate the action of PLD isozymes as novel targets and positive feedback regulators of Wnt signaling.
Here, we demonstrate that PLD isozymes, PLD1 and PLD2 are direct targets and positive feedback regulators of the Wnt/β-catenin signaling.
Furthermore, we show that an α-integrin subunit is a BMP target gene, identifying positive feedback between integrin signaling and BMP pathway activity that may contribute to robust cell fate decisions.
The most effective anti-thrombotic treatments currently used specifically target the ADP/P2Y12 positive feedback cascade, blocking the P2Y12 receptors and thus limiting platelet activation and aggregation and the risks of pathological thrombosis, particularly in the management of coronary heart disease [21].
These data indicate that Stat6, as both a PR cofactor and a target gene, mediates a positive feedback loop participating in the growth-inhibitory response to progesterone.
The authors went on to show that these miRNAs were transcriptionally activated by p53 and target MDM2, forming a positive feedback loop.
We, therefore, hypothesize that in case of p53 downstream targets, the foremost activated positive feedback in a coupled feedback circuit can rapidly induce the "on" state transition of the signaling system (p53 activating downstream target genes), and that then another delayed positive feedback (p53 suppressing miRNAs that target p53 downstream target genes) robustly maintains this "on" state.
Overall, these data demonstrate that scb is indeed a BMP target gene and identify a positive feedback loop in which BMP-dependent induction of scb expression further enhances BMP signal transduction via the activation of integrin signaling.
