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It should be noted that, despite the clear dominance, some participants reported a small but perceptual crescent of the non-dominant target around the target periphery.
The steep dose fall close to the target periphery demands high precision in the treatment delivery.
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Rehashing endocannabinoid antagonists: can we selectively target the periphery to safely treat obesity and type 2 diabetes?
However, the vast majority of OA-related treatments target the periphery; for example, nonsteroidal anti-inflammatory drugs act on local inflammatory processes.
We hypothesized that the core set of conserved receptor-binding residues would have unusually low mutational tolerance, but that the set of all receptor-binding residues would have typical levels of mutational tolerance since influenza routinely escapes from antibodies that target the periphery of the receptor-binding pocket (Koel et al., 2013).
At network level, targeting the periphery of the network means to directly stimulate the closure of more triangles.
But targeting the periphery along with the brain may be a way to get at the disease from both ends.
More precisely, we expect to target powerful peripheries with a gain of space (i.e., cost saving) by isolating both faces of the die with a porous silicon layer etched from the through wafer p-wells commonly encountered in top glass or planar technologies.
This fact probably explains why HA is able to escape from antibodies targeting the periphery of the receptor-binding pocket (Koel et al, 2013), and why only rare antibodies that penetrate deep into this pocket are broadly neutralizing (Whittle et al, 2011)." 3) The paper addresses the mutational tolerance and antigenic evolvability of HA.
This fact probably explains why HA is able to escape from antibodies targeting the periphery of the receptor-binding pocket (Koel et al., 2013), and why only rare antibodies that penetrate deep into this pocket are broadly neutralizing (Whittle et al., 2011).
In line with this notion, several biomarkers of B cell activity are significantly affected by treatment, both in the target organs and periphery.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com