Sentence examples for target pathway from inspiring English sources

Our data further provided evidence of target pathway engagement, as the anti-fibrotic effect of CZ415 was associated with inhibition of 4E-BP1 phosphorylation at residues demonstrated throughout our study to be critical for regulation of the collagen biosynthetic cascade.

However, such system relies on the complete recycling of NADH and may become limited when the target pathway results in excess NADH stoichiometrically.

With targeted therapies, it is often hypothesized that their effect may be specific to the subpopulation in which the target pathway is activated.

Together, these results reveal a Wnt-dependent osteogenic mechanism, and they provide a potential target pathway for designing therapeutics to promote bone formation.

Measurement of molecular target status, pharmacokinetic (PK) parameters of drug exposure, and pharmacodynamic (PD) endpoints of drug effects on target, pathway, and downstream biological processes are extremely important.

Metabolic engineering has made great strides in developing tools to optimize the flux through a target pathway, but the inherent characteristics of a particular enzyme within the pathway can still limit the productivity.

These results indicated that the gene signature analysis could classify the kinome-targeted agents in a target pathway-dependent manner.

As described above, the anticancer drugs were basically clustered in a target pathway-dependent manner.

However, the target pathway-based classification was more accurately achieved using the data of a single cancer cell line (Fig. 3).

Our data indicated that this gene expression-based analysis efficiently classified the oncogenic kinase inhibitors as well as other classes of agents in a target pathway-dependent manner.

The gene signature analysis further classified kinome-targeting agents depending on their target signaling pathways, and we identified target pathway-selective signature gene sets.