Sentence examples for target of this modification from inspiring English sources
Many assume the ultimate target of this modification to be India, the arch rival of Pakistan since 1947.
As discussed below, we found a conserved B/Y331 at the nucleotide-binding site in the B A interface, which is the likely target of this modification.
Given the fundamental roles of H3K18 hypoacetylation in cancer biology, we investigated the possibility of therapeutic targeting of this modification in mantle cell lymphoma (MCL), in which epigenetic alterations, including aberrant hypomethylation of the HDAC1 gene, are central to the disease process and in which conventional therapies are usually not effective.
Of the different methionines, we start the study using M213 as target of the modification since it was found to be sulfoxidized in the PrP chains of the infectious state [9], [10].
In contrast to H3K36me3, dimethylation of H3K36 is abundant throughout the genome (30 50% of histone H3 is dimethylated at H3K36), but targeting and functions of this modification are less well-understood.
The targeting of the modification enzymes to the specific sites is largely dependent on gene-specific transcription factors [43].
Spot 8 corresponding to a 50 kDa 15d-PGJ2-protein conjugate was one of the targets of the modification by biotinylated 15d-PGJ2, aseenen in Figure 8.
A knowledge of the proteins targeted by this modification is thus of utmost importance in deciphering its impact on the biology of the organism.
This lysine is the target of covalent modification by the retinal prosthetic group of these proteins and is under evolutionary constraints.
Interestingly, PER2 has been identified as another target of GSK3β 51, and this modification is involved in the phase control.
The sensitivity analysis method can determine the dominant modal parameters influencing the squeal occurrence in a regular way, and the dominant modal parameters will be set to be the target of structural modification attempted to eliminate the squeal mode.
