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This neighboring area is a main target of projections from motor cortex itself, as indicated by functional imaging in humans [32], and by anatomical [33] and electrophysiological evidence [34] in primates.
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The targets of projections from nearby neurons should share common features.
One study demonstrated that the targeting of projections from myenteric nitrergic neurons is controlled by GDNF during perinatal and postnatal development.
The results predict distinct activity patterns of interneurons and highlight the need to uncover the target specificity of projections in future experiments.
The hippocampus is involved in short and long-term memory processing [4] and one important target of hippocampal projections is the nucleus accumbens (NAC), a region involved in drug reward circuitry [for review, 5].
For this experiment, we performed rescue in either the NAc or the amygdala to also determine if TH rescue in one target of DA projections would influence DA levels in another, non-injected region.
Given that these thalamic neurons are not a major target of dopaminergic projection, it is likely that the counteractive mechanism is not under direct control of dopamine.
Alternatively, QC itself may be anterogradly transported and released in target regions of projection neurons, and then modify extracellularly deposited N-truncated Aβ peptides.
In addition to the local formation of pE-Aβ aggregates at sites of QC-immunoreactive somata, pE-Aβ peptides may be released in target areas of projection neurons and may form Aβ plaques in brain regions devoid of QC and/or APP expression.
There were no observable differences between control and autistic subjects in the locations of target projections of either tract, even at the lowest uncorrected threshold (P < 0.05).
Muslims today are vulnerable targets for projections of Americans' unidentified anxieties.
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