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We focused on the search for α-helical coiled coil motifs that, in general, do not exhibit a folding problem, and are a target of effective antibodies for several current malaria vaccine candidates (eg. LSA-1 [3], LSA-3 [4], MSP-3 [5], and MSP-6 [6] and other pathogens [7]. MSP-1, another leading malaria vaccine [8], also contains predicted α-helical coiled coil regions (unpublished results).
They are therefore the target of effective therapeutic drugs against thrombosis and inflammation (1).
Hospital employees report being motivated more by intrinsic factors, implying that these should be a target of effective employee motivation.
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"This analysis adds valuable new scope to our understanding of pain... It may help shape future research, development and targeting of effective pain interventions, including complementary health approaches". The prevalence of chronic pain in America also lies at the root of an ongoing epidemic of prescription painkiller abuse.
"Improvements in care and outcome for patients with breast cancer will involve improved targeting of effective therapies to appropriate patients," he said.
Collectively the current understanding of PACAP and its receptors in relation intracranial structures and brain provide valuable information as potential targets of effective future therapeutics. .
Collectively the current understanding of PACAP and its receptors in relation intracranial structures and brain provide valuable information as potential targets of effective future therapeutics.
In summary, we conducted an siRNA screen to identify DNA repair pathways important for HIV infection and identified BER as being highly represented among targets of effective siRNAs.
It is nevertheless encouraging to qualitatively observe fortuitous temporal targeting of effective control of the primary malaria vector, complemented by successful all-year-round abatement of the secondary vectors.
This could enable geographic targeting of effective interventions for enhancing early and timely detection and management of diabetes in those communities.
3 47 48 Hence, the particularly larger reduction in mortality in women <50 years old may reflect better targeting of effective treatments and response to treatments.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com