Sentence examples for target mediated from inspiring English sources
The actual number is probably higher because the clinical doses at which drugs are studied often saturate the target mediated elimination pathway, thereby masking the nonlinear PK.
Most mAbs display target mediated drug disposition (TMDD), which can have significant consequences on the study designs of preclinical and clinical studies.
He describes the impact of glycosylation, target mediated drug disposition (TMDD), anti-drug antibody (ADA), route of administration, and formulation on antibody PK (Liu, 2017).
This singular behaviour of the polaron concentration has a direct impact on the uranium sublattice partial molar heat capacity and an indirect effect on the energy interactions between the electronic and ionic structure of the target mediated by these polarons.
Therefore, the effect of monocytes on NK cells are reminiscent of the effect of anti-CD16 mAb or target mediated induction of split anergy in NK cells [16], [19].
Animal models may provide valuable insights into disease processes, but are limited in their ability to demonstrate specific target mediated effects that correspond to observations in RA.
However, the analysis cannot distinguish direct regulatory interactions from indirect influences regulator-target mediated by secondary regulatory pathways.
Although this might suggest target-mediated specific tumour uptake, another study design would have been more informative on this point [21].
Recently high throughput cross-interaction assays were developed to screen mAbs for off-target mediated clearance.
For the commonly used classes of biologics (such as human monoclonal antibodies), biodistribution profiles may be compared to those of other therapeutics of the same class and compounds with unexpected off-target mediated uptake may be identified.
Thus, we believe that the translation blocking AMO experiments may have some off-target mediated effects that could have contributed to the observed phenotype.
