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An execution engine is in charge of managing the described application flow by identifying providers, requesting resources, receiving related event notifications, and providing output resources to finally deliver the target functionality.
These can be proteolytic degradation, inhibition of target functionality and target production [ 2, 3].
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Automatic transfer of data and control is usually available only whenever an API describing the integration target object functionalities exists.
XPS and FTIR revealed that the CMK-3 target functionalities for immobilization were the surface oxygen groups.
Based on CAMD, optimal chemical products can be designed by identifying the molecule with the best properties that correspond with the target functionalities of the product.
These data were used to test equivalent circuit models derived from the composite constituent properties, and to assess their potential to design composites for target functionalities at higher temperature.
This observation inspired them to set up a metal constraint in Glide, which requires that a ligand atom lies within a certain region of the binding site in order to interact with specific target functionalities.
Both cytotoxicity and apoptosis studies show that the DOX-loaded nanomicelles were more potent than drug nanomicelles without nuclear targeting functionality.
The integration of magnetic and reduction dual-responsiveness, folate-receptor-mediated targeting functionality and fluorescence visualization into the versatile microcapsules make MSRS-CS-MCs promising nanocarriers for future biomedical applications.
Although much effort has gone into developing circulating nanocarriers with targeting functionality for systemic administration, another alternative and straightforward approach is to utilize formulations to be administered directly to the site of action, such as pulmonary and intratumoral delivery.
As drug carriers, the obtained spherical MSRS-CS-MCs with the average size of 500 nm showed excellent magnetic responsive ability, favorable selectively folate-receptor-mediated targeting functionality to the HeLa cells, and attractive reduction-responsive release ability for hydrophobic drugs.
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