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This makes IL-6 a potentially powerful target for tolerance-generating therapies (Bettelli et al., 2006; Korn et al., 2008).
The study provided a list of gene targets for tolerance engineering in cyanobacterium Synechocystis.
For example, if heat-shock genes are more numerous due to gene duplication in D. melanogaster, the target for and/or tolerance of TE insertion would be larger in D. melanogaster populations than in other species.
Specific biomarkers indicating immune quiescence and representing targets for novel tolerance induction protocols are needed.
Together with our results, these examples show that multidrug transporters are putative metabolic engineering targets for increased tolerance to HMF and furfural.
By investigating how elevated [O3] affects the transcriptome of reproductive tissues, we can begin to understand the distinct responses in different tissues and identify potential targets for improving tolerance.
Although the α-subunit of farnesyltransferase (AtFTA) is also implicated in ABA sensing, the effectiveness of using such a gene target for improving drought tolerance in a crop plant has not been validated.
Therefore, this differential control of the fate of pyruvate may be enough to drive the increase in glycolysis, and may also be a target for enhancing hypoxia tolerance.
This work presents a case study that an individual enzyme in the Calvin cycle may be a useful target for genetically engineering stress tolerance in horticultural crops.
The PRO1 gene would be an alternative target for further improving strain tolerance against lignocellulose-derived inhibitors.
The system based network approach developed allows the identification of novel gene targets for improved ethanol tolerance and supports the highly complex nature of ethanol tolerance in yeast.
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