Sentence examples for target for suppressing from inspiring English sources

Because Jak-3 is critical to IL2-dependent signaling and proliferation, its sensitivity to PGE2 may make it a prime target for suppressing IL2-dependent cell cycle progression in T cells.

Thus this pathway is an ideal drug target for suppressing tumor growth and attenuating chemoresistance.

Legumain, a member of the asparaginyl endopeptidase family, was considered to be overexpressed by TAMs, which may be a target for suppressing tumor growth.

To this end, we show that Rac1 GTPase, an EMT regulator, may be a useful target for suppressing multiple subpopulations of CS/PCs and CS/PC plasticity.

More recently, NKCC1-mediated chloride uptake has also been suggested to be an important mechanism regulating the peripheral excitability of sensory neurons [ 6, 23, 25] and may represent a useful peripheral target for suppressing afferent nerve excitability [ 6, 23, 26].

Furthermore, since TTX or anticonvulsant drugs inhibit metastatic cell behaviour, VGSCs could represent a novel target for suppressing SCLC.

Taken together, these findings suggest that HDAC2 and HDAC3, especially HDAC3, may be important regulators for the proliferation and invasion of HCC cells, which at least partly explained the mechanism of tumor recurrence in vivo, and could be possible targets for suppressing tumor viability.

To explore the molecular targets for suppressing bone destruction in RA, we performed a genome-wide screening of RANKL-inducible genes.

Furthermore, we find that the mean abundance of fluctuating IAP is positively correlated with the degree of cell-to-cell variability, thus making IAP a potential target for therapeutically suppressing the stochasticity of intrinsic apoptosis response across cell population in treating diseases such as cancer.

Its near universal applicability coupled with its pinpoint accuracy for suppressing target proteins has altered the landscape of many fields.

Angiogenesis requires endothelial cell survival and proliferation, which depend upon cytokine stimulation together with integrin-mediated cell adhesion to extracellular matrix; however, the question of which specific integrins are the best targets for suppressing neovascularization is controversial and unresolved.