Sentence examples for target for efficacy from inspiring English sources

Although it is generally accepted that endothelial ACE is an important target for efficacy of any ACE inhibitor, inhibition of adventitial ACE may be just as relevant, particularly in the management of hypertension, heart failure, and/or ischemic heart disease (Zhou et al. 2002).

These Selective Targeting for Efficacy in Lung Cancer, Lower Adverse Reaction (STELLAR™) trials represent the largest randomized phase III programs in patients with NSCLC and a poor performance status.

Identifying and hitting clinical PK-PD targets for efficacy was an early goal of pharmacometric approaches.

Furthermore, the role of fingers in transmission of NoVs was quantified and these data can be useful in risk assessment models and to establish target levels for efficacy of transmission intervention methods.

This work identifies FosB as a primary fosfomycin-modifying pathway of S. aureus and establishes the enzyme as a potential therapeutic target for increased efficacy of fosfomycin against the pathogen.

Clinically, target occupancy can be used to unequivocally confirm "drug-on-target" (proof of mechanism), (Morgan et al. 2012) guide clinical dose selections, and enable data-driven clinical "Go/No Go" decisions depending on whether the onset of side effects occurs prior to or after desired target occupancy range for efficacy (Wong et al. 2009).

Continuous research worldwide is focusing on developing better therapeutics as well as finding novel druggable targets for better efficacy.

Second, the use of obidoxime would enable the identification of other targets for obidoxime efficacy than AChE reactivation alone (Maxwell et al. 2006).

The time-dependent intra-mitochondrial distribution patterns of T-3-BP-AuNPs indicated that the 3-BP delivered by T-AuNPs will be able to attack all of its intracellular targets for maximum efficacy.

Moreover, the microbiome is a very attractive target for improving drug efficacy and safety due to the opportunities to manipulate its composition.

We also propose that the design of CRAds should consider stromal cells as a potential target for achieving improved efficacy.