Sentence examples for target engagements from inspiring English sources

Although few phenotypic effects have been reported using these compounds apart from their cellular target engagements, initial data point to a role of BRD9/7 in inflammation.

Practice multiple target engagements, rapid reloading, shooting on the move, transitioning to your sidearm and various other situations.

They demonstrated a 55-fold improvement in target engagement over the control (Neiwoehner et al. 2014).

· Evidence of downstream pharmacodynamic effects as a consequence of target engagement.

These radiotracers also may provide measurements of target engagement for therapeutic interventions.

Receptor occupancy is also very important experimental descriptor for evaluating target engagement by the examined drug.

Enhanced target engagement of the Brain Shuttle module translates into a significant improvement in amyloid reduction.

Ethanolamides are considered to be potential pharmacodynamic biomarkers to determine target engagement for FAAH inhibition by novel pharmaceutical agents.

The compound was used to demonstrate target engagement and inhibition of Cat K in an in vivo dog PD model.

Using two representative antagonists, 2c and 4c, the GPR91 target engagement was subsequently demonstrated using the designed pharmacodynamic assay.

In this paper we address experimental design issues related to maximizing the information content about target engagement.