Sentence examples for target engagement from inspiring English sources

USP7 target engagement and specificity in MCF7 cells.

Metabolomics and isotope tracer studies demonstrate effective cellular target engagement.

Our application of CETSA Classics to AR revealed that target engagement of antagonist does not modulate AR thermal stability, while target engagement of agonist causes a thermal stabilisation.

In contrast, target engagement could be observed with known AR antagonists in the presence of DHT at different time points, allowing kinetic analysis of target engagement.

Cellular target engagement of AR agonists or antagonists by CETSA HT.

These results suggest that these compounds cause rapid AR degradation precluding measures of target engagement.

Hence this effect constitutes a proximal measure of antagonist target engagement.

CETSA HT detects antagonism of agonist target engagement to derive apparent intracellular Ki.

(b) ITDRFCETSA experiments at 46 °C to determine the potency of agonist target engagement.

Simon, G. M., Niphakis, M. J. & Cravatt, B. F. Determining target engagement in living systems.

Dubach, J. M. et al. Quantitating drug-target engagement in single cells in vitro and in vivo.