Sentence examples for target efficacious from inspiring English sources
The design of any such future clinical studies to target efficacious and tolerable exposures at lower doses in patients with severe RI or ESRD will be guided by additional PK simulations.
The data collected are then analyzed using network/netwire connecting methods in order to provide a wider view of the pathways involved and of the importance of such information in identifying additional proteins that could serve as novel druggable targets for efficacious cancer therapy.
Collaborative and multi-disciplinary scientific study is thus a research priority in order to characterize the primary drivers of TIC and develop targeted and efficacious treatment strategies.
We therefore propose c-CBL as an efficacious target for lung cancers in African-Americans that needs to be further substantiated.
This in turn suggests that EP2/survivin may be an efficacious target for chemoprevention or therapy of skin cancer [ 60].
Overexpression of E2F1 promotes the development of MDR in gastric carcinoma, suggesting that E2F1 may represent an efficacious target for gastric cancer therapy.
Because of its impact on cell-growth and -survival pathways, E2 signaling has proven to be an efficacious target for ER-positive breast cancer therapy.
E2 between 20 and 40 pg/ml was therefore considered a reasonable target to evaluate efficacious endometrial pain response while minimizing BMD effects.
Translational PK-PD modeling can support the design of FIH studies by providing estimates of efficacious target exposures, associated dose regimens, and guidance in selection of biomarker and optimal sampling time points for exposure and biomarkers.
Given previous reports that the transformation activity of KRAS is dependent on RAC1 (Qiu et al., 1995), it seems likely that RAC1 would remain an efficacious target even in the setting of a KRAS mutation.
These studies support the contention that NURR1 could be an efficacious target in cancer chemoprevention and therapy, as well as a potential biomarker for treatment efficacy in breast cancer.
