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He was also able to check that no accidental edits, or "off target" effects, had occurred.
This oligo design eliminates off target effects starting at 16 nucleotides.
Given an input disease gene set, the algorithm selected drugs that maximized on target effects and minimized off target effects.
This made off target effects unlikely.
On the other hand, valsartan has off target effects.
Similar(55)
It absolutely minimises off-target effects".
Despite its potential, PDT can suffer from off-target effects.
Monitoring off-target effects of the CRISPR-Cas9 system.
Together, our results indicate minimal off-target effects of Cas9, suggesting it is feasible to screen for hiPSC clones not harbouring off-target effects.
Hruscha, A. et al. Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish.
"They should be able to avoid nonspecific, off-target effects," says Gordon.
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