Sentence examples for target effect on from inspiring English sources

The phenomenology underlying the polarimetric technique is better expressed by using the Stokes-Mueller formalism [29], which enables one to completely describe the intensity and the polarization state of radiation by means of Stokes vectors, and the medium or target effect on the light polarization state through Mueller matrices.

Interestingly we found that both FLP and FLPe had an 'off target' effect on blood stage development in culture, resulting in a reduced growth rate and/or arrest in parasite development.

S6 phosphorylation was unaltered in the presence or absence of Akti-1/2 indicating that the inhibitor has no off target effect on mTORC1 and p70S6K, and the PDK1-IFPC::IFPN-AKT1 complex is responsible for mTORC1-dependent p70S6K activation in the presence of Akti-1/2 (Figure S5).

Other data elaborate that in addition to its positive modulating effect on Akt signalling, ROS is capable of exerting a direct target effect on Akt itself under conditions of oxidative stress (Murata et al, 2003; Hussain et al, 2011; Shearn et al, 2011a).

The siRNAs against GSK3 β were a group of four different siRNAs designed to minimize the off-target effects (ON-TARGETplus; Thermo Scientific Dharmacon, Chicago, IL, USA).

RD cells were reverse transfected with SIRT1-siRNA or SIRT2-siRNA molecules each consisting of four individual siRNAs targeting different sirtuin regions to avoid off-target effects (ON-TARGETplus Human SIRT1 (23411) siRNA and Human SIRT2 (22933)—SMARTpool) using DharmaFECT1 transfection reagent.

Higher concentration of rapamycin (up to 1 µM) did not further reduce the cell viability (Figure S6), compatible with 10 nM of rapamycin completely inhibiting mTORC1 and higher concentration of rapamycin not exhibiting additional off target effects on cell viability.

However, it is possible that the FAS II inhibitors used are having off target effects on parasite growth.

Such drugs would have to be screened, as has been done in the past, for off target effects on other cellular polymerases.

Although some individual siRNAs targeting FOXO6 had off target effects on other FOXOs, direct targeting of FOXOs 1, 3a, and 4 had no effect on SOX2 expression, further supporting the specificity of the FOXO6 effect.

The second conclusion is that the design of the target sequences needs to focus on avoiding off target effects on selected species that should be protected (like for instance bees) or that are most common in the respective environment.