There are project teams organized to investigate molecular pathways and advance therapeutic targets to a development stage," Burkly notes.
More generally, the high association of gene expression at the early developmental stage (e.g. juvenile leaf) with a target trait at a later development stage (e.g. in seeds) is due to allelic, cis-acting variation rather than being a read-out of a transcription network, as hypothesized previously for the association in maize hybrids of transcript abundance variation in leaves with grain yield.
A practical and efficient structural damage detection method must consider the characteristics of the target structure and damage in the development stage.
Furthermore, the TTM supports the design and implementation of interventions targeting particular organizational development stages and therefore, is useful to "reduce resistance, increase participation, reduce dropout and increase change progress among employees" [[ 36], p. 247].
Due to the cancer heterogeneity, different tumor models will be needed according to the development stages: target validation, proof of concept of target inhibition by a lead compound (small molecules or biotherapeutics), or candidate selection for further clinical development.
In order to ensure that the set targets are achieved, the measures laid down in this article should support not only the research and development stage but also the operational stage.
However, few clinical trials concerning CART cells targeting CSCs registered on the website www.clinicaltrials.gov indicate that this cancer therapy is still in the exploration and development stage.
WinVista is still a development stage company.
New Media Investment Group, Inc. is a development stage company.
YouOS is obviously in the development stage.
Early in its development stage, yet learning.
