Sentence examples for target determinants from inspiring English sources

and characteristics of the target molecule's environment (membrane localization, glycocalyx, clustering, etc).. Quantitative parameters of ligand affinity and surface density on a carrier have to be determined empirically because surface density and clustering of target determinants in vivo remain to be characterized.

Change methods are used to target determinants such as attitude or self-efficacy (e.g. modeling) that are in turn thought to influence the behavior.

Functions of target determinants are important in the context of drug delivery.

Not all endothelial target determinants are "endothelial-specific markers", such as E-selectin.

Monomolecular ligands interact with target determinants either in bivalent (e.g., antibodies themselves) or monovalent fashion (e.g., Fab-fragment conjugates and scFv-fragment fusion proteins).

It uses ligands that bind to molecules uniquely present or enriched in a cell, tissue, or pathological structure of interest (target determinants).

This highly unusual empirical finding can be interpreted as an increase in accessibility of an epitope to its ligand due to conformational changes in the target determinant molecule induced by binding of a paired "stimulatory" ligand to its adjacent epitope.

A target determinant should ideally meet the following criteria: (i) it anchors a carrier to endothelium in the area of interest; (ii) it provides desirable subcellular addressing; and (iii) it is not adversely affected by carrier binding in the context of disease treatment.

A recent study by Nielsen and colleagues reveals several miR targeting determinants [ 32].

The presence of other membrane-targeting determinants in PA effectors provides additional specificity in their targeting to individual cellular membranes.

However, researchers have now identified nuclear targeting determinants, which resemble eukaryotic nuclear localization signals, and these have been found to affect targeting to the nucleus [ 157].