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It is common knowledge that the performance of docking procedures is generally target dependent.
These values represent an estimation of the target (dependent) variable for the new observations.
Herein, currently used in silico screening techniques and their utility on a comparative and target dependent basis is discussed.
Further extension toward additional targets can facilitate a systematic comparison of the virtual screening performance of docking tools and scoring functions in a target dependent way.
Therefore, promiscuity, as well as "lead-like" and "drug-like" properties are assay and target dependent, and should be evaluated within a particular context.
(Pre-) clinical studies of various bsAb constructs have shown impressive results in terms of immune effector cell retargeting, target dependent activation and the induction of anti-tumor responses.
Similar(36)
When you define data in C, the data you get in memory is compilation-target dependent.
In the presence of target, the target-dependent hammerhead aptazyme cleaves off.
Classical protein-ligand scoring functions are not capable of inter-target score comparison, since the absolute values are target-dependent.
Another important factor for target-dependent screening performance differences is the complexity of the microenvironment of metal-containing targets [29, 38].
In general, we observed that the screening performance differences between the two preparations are variable in a target-dependent manner for both docking programs.
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